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Göteborgs universitets publikationer

Interleukin-26: An Emerging Player in Host Defense and Inflammation

Författare och institution:
Sara Tengvall (Institutionen för medicin); K. F. Che (-); A. Linden (-)
Publicerad i:
Journal of Innate Immunity, 8 ( 1 ) s. 15-22
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The production of interleukin (IL)-26 was initially attributed to T cells, and in particular to Th17 cells. However, more recent findings indicate IL-26 production in natural killer (NK) cells, macrophages and fibroblast-like cells as well. It is known that IL-26 binds to the IL-20R1/IL-10R2 receptor complex on certain target cells, where it causes specific intracellular signaling and the secretion of IL-1 beta, IL-8 and TNF-alpha. In line with this type of proinflammatory role, IL-26 also increases chemotaxis of human neutrophils. Interestingly, high levels of IL-26 are present even in normal human airways, and endotoxin exposure further enhances these levels; this indicates involvement in antibacterial host defense. Studies on acute inflammatory disorders are few but there are studies showing the involvement of IL-26 in rheumatoid arthritis and inflammatory bowel disease. In conclusion, IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. (C) 2015 S. Karger AG, Basel
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Asthma, Cancer, Crohn's disease, Interleukin-17, Rheumatoid arthritis, Th17 cells, Ulcerative colitis, epithelial-cells, cutting edge, family, polymorphisms, receptor-2, cytokines, targets, members, ak155, 12q15, Immunology
Postens nummer:
Posten skapad:
2016-02-22 11:17
Posten ändrad:
2016-02-22 11:18

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