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Göteborgs universitets publikationer

Adjunctive Systemic and Local Antimicrobial Therapy in the Surgical Treatment of Peri-implantitis: A Randomized Controlled Clinical Trial

Författare och institution:
Olivier Carcuac (Institutionen för odontologi); Jan Derks (Institutionen för odontologi); Georgios Charalampakis (Institutionen för odontologi); Ingemar Abrahamsson (Institutionen för odontologi); Jan Wennström (Institutionen för odontologi); Tord Berglundh (Institutionen för odontologi)
Publicerad i:
Journal of Dental Research, 95 ( 1 ) s. 50-57
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The aim of the present randomized controlled clinical trial was to investigate the adjunctive effect of systemic antibiotics and the local use of chlorhexidine for implant surface decontamination in the surgical treatment of peri-implantitis. One hundred patients with severe peri-implantitis were recruited. Surgical therapy was performed with or without adjunctive systemic antibiotics or the local use of chlorhexidine for implant surface decontamination. Treatment outcomes were evaluated at 1 y. A binary logistic regression analysis was used to identify factors influencing the probability of treatment success, that is, probing pocket depth <= 5 mm, absence of bleeding/suppuration on probing, and no additional bone loss. Treatment success was obtained in 45% of all implants but was higher in implants with a nonmodified surface (79%) than those with a modified surface (34%). The local use of chlorhexidine had no overall effect on treatment outcomes. While adjunctive systemic antibiotics had no impact on treatment success at implants with a nonmodified surface, a positive effect on treatment success was observed at implants with a modified surface. The likelihood for treatment success using adjunctive systemic antibiotics in patients with implants with a modified surface, however, was low. As the effect of adjunctive systemic antibiotics depended on implant surface characteristics, recommendations for their use in the surgical treatment of peri-implantitis should be based on careful assessments of the targeted implant ( NCT01857804).
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
dental implant, amoxicillin, implant surface decontamination, radiographs, logistic regression, consensus report, follow-up, bone loss, diseases, lesions, dogs, Dentistry, Oral Surgery & Medicine
Postens nummer:
Posten skapad:
2016-01-15 08:53

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