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Göteborgs universitets publikationer

Genomic encyclopedia of bacteria and archaea: sequencing a myriad of type strains.

Författare och institution:
Nikos C Kyrpides (-); Philip Hugenholtz (-); Jonathan A Eisen (-); Tanja Woyke (-); Markus Göker (-); Charles T Parker (-); Rudolf Amann (-); Brian J Beck (-); Patrick S G Chain (-); Jongsik Chun (-); Rita R Colwell (-); Antoine Danchin (-); Peter Dawyndt (-); Tom Dedeurwaerdere (-); Edward F DeLong (-); John C Detter (-); Paul De Vos (-); Timothy J Donohue (-); Xiu-Zhu Dong (-); Dusko S Ehrlich (-); Claire Fraser (-); Richard Gibbs (-); Jack Gilbert (-); Paul Gilna (-); Frank Oliver Glöckner (-); Janet K Jansson (-); Jay D Keasling (-); Rob Knight (-); David Labeda (-); Alla Lapidus (-); Jung-Sook Lee (-); Wen-Jun Li (-); Juncai Ma (-); Victor Markowitz (-); Edward R.B. Moore (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Mark Morrison (-); Folker Meyer (-); Karen E Nelson (-); Moriya Ohkuma (-); Christos A Ouzounis (-); Norman Pace (-); Julian Parkhill (-); Nan Qin (-); Ramon Rossello-Mora (-); Johannes Sikorski (-); David Smith (-); Mitch Sogin (-); Rick Stevens (-); Uli Stingl (-); Ken-Ichiro Suzuki (-); Dorothea Taylor (-); Jim M Tiedje (-); Brian Tindall (-); Michael Wagner (-); George Weinstock (-); Jean Weissenbach (-); Owen White (-); Jun Wang (-); Lixin Zhang (-); Yu-Guang Zhou (-); Dawn Field (-); William B Whitman (-); George M Garrity (-); Hans-Peter Klenk (-)
Publicerad i:
PLoS biology, 12 ( 8 ) s. e1001920
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Microbes hold the key to life. They hold the secrets to our past (as the descendants of the earliest forms of life) and the prospects for our future (as we mine their genes for solutions to some of the planet's most pressing problems, from global warming to antibiotic resistance). However, the piecemeal approach that has defined efforts to study microbial genetic diversity for over 20 years and in over 30,000 genome projects risks squandering that promise. These efforts have covered less than 20% of the diversity of the cultured archaeal and bacterial species, which represent just 15% of the overall known prokaryotic diversity. Here we call for the funding of a systematic effort to produce a comprehensive genomic catalog of all cultured Bacteria and Archaea by sequencing, where available, the type strain of each species with a validly published name (currently∼11,000). This effort will provide an unprecedented level of coverage of our planet's genetic diversity, allow for the large-scale discovery of novel genes and functions, and lead to an improved understanding of microbial evolution and function in the environment.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper ->
Archaea, classification, genetics, Bacteria, classification, genetics, Databases, Genetic, Genome, Archaeal, genetics, Genome, Bacterial, genetics, Genomics, Phylogeny, Sequence Analysis, DNA
Postens nummer:
Posten skapad:
2016-01-09 06:12
Posten ändrad:
2016-01-11 11:08

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