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Göteborgs universitets publikationer

Increased risk of renal biopsy complications in patients with IgA-nephritis

Författare och institution:
B. Peters (-); B. Stegmayr (-); Y. Andersson (-); H. Hadimeri (-); Johan Mölne (Institutionen för biomedicin, avdelningen för patologi)
Publicerad i:
Clinical and Experimental Nephrology, 19 ( 6 ) s. 1135-1141
ISSN:
1342-1751
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Background The aim of this study was to investigate if specific clinical and histological findings can be related to biopsy complications to enable more closely monitoring patients at high risk. Methods Results from 1081 biopsies (994 patients, median age 54.5 years; 896 native and 185 transplant kidney biopsies) were included. Diagnostic quality, morphology, clinical data and complications were prospectively registered. Results In native kidney biopsies, the most common diagnosis was IgA-nephritis, while in transplant kidney biopsies it was rejection. Patients with IgA-nephritis had a higher risk of major complications (11.7 versus 6.4 %, Odds Ratio (OR) 1.8, Confidence Interval (CI) 1.1-3.2) when compared to patients with other diseases. In native kidney biopsies, patients who experienced major complications had higher degrees of glomerulosclerosis (31 versus 20 %, p = 0.008), whereas in transplant kidney biopsies, patients had higher degrees of interstitial fibrosis (82 versus 33 %, p < 0.001) when compared to patients without major complications. IgA-nephritis-patients had a higher risk of re-biopsies (4.7 versus 1.3 %, OR 4, CI 1.5-11) than patients with other diseases. Patients with native kidneys who needed re-biopsies were younger (42.6 versus 52.3 years, p = 0.031) and had a higher degree of interstitial fibrosis (63 versus 34 %, p = 0.046). Conclusions Patients with IgA-nephritis have an increased risk of major biopsy complications. The risk of re-biopsies was higher in younger individuals and in patients with IgA-nephritis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
Kidney biopsy, Biopsy complications, IgA-nephritis, Interstitial fibrosis, Glomerulosclerosis, henoch-schonlein purpura, fibrin stabilizing factor, factor-xiii, kidney, biopsies, children
Postens nummer:
230194
Posten skapad:
2016-01-08 14:18
Posten ändrad:
2016-05-02 11:18

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