transparent gif

 

Ej inloggad.

Göteborgs universitets publikationer

Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skovde Cohort

Författare och institution:
Bledar Daka (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Josefin Olausson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Charlotte A. Larsson (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Margareta Hellgren (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); L. Rastam (-); Per-Anders Jansson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Ulf Lindblad (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa)
Publicerad i:
Bmc Cardiovascular Disorders, 15 s. Article number 146
ISSN:
1471-2261
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Background: The vasoconstricting peptide endothelin 1 has been proposed to be a marker of cardiovascular disease. Our aim was to investigate whether circulating endothelin-1 levels predict coronary heart disease (CHD) in Sweden. Methods: In 2002-2005, 2816 adult participants (30-74 years) were randomly selected from two municipalities in south-western Sweden. Cardiovascular risk factors and endothelin-1 levels were assessed at baseline, and incident CHD was followed-up in all participants through 2011. After exclusion of 50 participants due to known CHD at baseline and 21 participants because of unsuccessful analysis of endothelin-1, 2745 participants were included in the study. In total, 72 CHD events (52 in men and 20 in women) were registered during the follow-up time. Results: We showed that baseline circulating endothelin-1 levels were higher in women with incident CHD than in women without CHD (3.2 pg/ml, SE: 0.36 vs 2.4 pg/ml, SE: 0.03, p = 0.003) whereas this difference was not observed in men (2.3 pg/ml, SE: 0.16 vs 2.3 pg/ml, SE: 0.04, p = 0.828). An age-adjusted Cox proportional regression analysis showed an enhanced risk of CHD with increasing baseline endothelin-1 levels in women (hazard ratio (HR) = 1.51, 95 % CI = 1.1-2.1, p = 0.015) but not in men (HR = 0.98, 95 % CI = 0.8-1.2, p = 0.854). Furthermore, the predictive value of endothelin-1 for incident CHD in women was still significant after adjustments for age, HOMA-IR, apolipoprotein (apo)B/apoA1 and smoking (HR = 1.53, CI = 1.1-1.2, p = 0.024).
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper ->
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ->
Folkhälsomedicinska forskningsområden
Nyckelord:
Coronary heart disease, Endothelin-1, Prospective study, Skaraborg project, PERIPHERAL VASCULAR-DISEASE, MYOCARDIAL-INFARCTION, CARDIOVASCULAR-DISEASE, POSTMENOPAUSAL WOMEN, DIABETES-MELLITUS, FREE, TESTOSTERONE, PLASMA, HYPERTENSION, SERUM, RISK
Postens nummer:
228897
Posten skapad:
2015-12-22 09:15
Posten ändrad:
2016-05-25 15:38

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007