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Göteborgs universitets publikationer

Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I.

Författare och institution:
Johan Svensson (Centre for Bone and Arthritis Research); Klara Sjögren (Centre for Bone and Arthritis Research); Malin Levin (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Jan Borén (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet); Åsa Tivesten (Wallenberglaboratoriet & Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Claes Ohlsson (Centre for Bone and Arthritis Research & Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition)
Publicerad i:
Endocrine, 52 ( 3 ) s. 550-560
ISSN:
1559-0100
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The role of endocrine IGF-I for atherosclerosis is unclear. We determined the importance of circulating, liver-derived IGF-I for fatty streak formation in mice. Mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice, serum IGF-I reduced by approximately 80 %) and control mice received an atherogenic (modified Paigen) diet between 6 and 12 months of age. At study end, Oil Red O staining of aortic root cryosections showed increased fatty streak area and lipid deposition in female but not in male LI-IGF-I(-/-) mice compared to controls. Mac-2 staining of aortic root and measurements of CD68 mRNA level in femoral artery revealed increased macrophage accumulation in proportion to the increased fatty streak area in female LI-IGF-I(-/-) mice. Moreover, female LI-IGF-I(-/-) mice displayed increased serum cholesterol and interleukin-6 as well as increased vascular cell-adhesion molecule 1 (VCAM1) mRNA levels in the femoral artery and elevated VCAM1 protein expression in the aortic root. Thus, increased diet-induced fatty streak formation in female LI-IGF-I(-/-) mice was associated with increased serum cholesterol and signs of systemic inflammation, endothelial activation, lipid deposition, and macrophage infiltration in the vascular wall.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes ->
Endokrinologi
Postens nummer:
228858
Posten skapad:
2015-12-21 14:25
Posten ändrad:
2016-06-27 14:14

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