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NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance.

Författare och institution:
Anna Martner (Sahlgrenska Cancer Center); Anna Rydström (Sahlgrenska Cancer Center); Rebecca E Riise (Sahlgrenska Cancer Center); Johan Aurelius (Sahlgrenska Cancer Center & Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Mats Brune (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Robin Foà (-); Kristoffer Hellstrand (Sahlgrenska Cancer Center); Fredrik B Thorén (Sahlgrenska Cancer Center)
Publicerad i:
Oncotarget, 6 ( 40 ) s. 42569-74
ISSN:
1949-2553
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
In a phase IV trial, eighty-four patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose human recombinant interleukin-2 (IL-2) to prevent relapse in the post-consolidation phase. Aspects of natural killer (NK) cell biology were analyzed before and during immunotherapy with focus on outcome in older patients. In younger (<60 years old, n = 37) and older patients (>60 years old, n = 47), treatment with HDC/IL-2 resulted in an expansion of CD56bright and CD16+ NK cells in blood along with an increased NK cell expression of the natural cytotoxicity receptors (NCR) NKp30 and NKp46. In older patients, a high expression of NKp30 or NKp46 on CD16+ NK cells before and during therapy predicted leukemia-free and overall survival. These results suggest that NK cell functions determine relapse risk and survival in older AML patients and point to biomarkers of efficacy in protocols for remission maintenance.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Cancer och onkologi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Radiologi och bildbehandling ->
Radiologi
Postens nummer:
227424
Posten skapad:
2015-12-07 11:35
Posten ändrad:
2016-05-12 16:06

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