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Göteborgs universitets publikationer

Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation

Författare och institution:
Johan Bengtsson-Palme (Institutionen för biomedicin, avdelningen för infektionssjukdomar); D. G. Joakim Larsson (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
Environment International, 86 s. 140-149
ISSN:
0160-4120
E-ISSN:
1873-6750
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
There are concerns that selection pressure from antibiotics in the environment may accelerate the evolution and dissemination of antibiotic-resistant pathogens. Nevertheless, there is currently no regulatory system that takes such risks into account. In part, this is due to limited knowledge of environmental concentrations that might exert selection for resistant bacteria. To experimentally determine minimal selective concentrations in complex microbial ecosystems for all antibiotics would involve considerable effort. In this work, our aim was to estimate upper boundaries for selective concentrations for all common antibiotics, based on the assumption that selective concentrations a priori need to be lower than those completely inhibiting growth. Data on Minimal Inhibitory Concentrations (MICs) were obtained for 111 antibiotics from the public EUCAST database. The 1% lowest observed MICs were identified, and to compensate for limited species coverage, predicted lowest MICs adjusted for the number of tested species were extrapolated through modeling. Predicted No Effect Concentrations (PNECs) for resistance selection were then assessed using an assessment factor of 10 to account for differences between MICs and minimal selective concentrations. The resulting PNECs ranged from 8 ng/L to 64 μg/L. Furthermore, the link between taxonomic similarity between species and lowest MIC was weak. This work provides estimated upper boundaries for selective concentrations (lowest MICs) and PNECs for resistance selection for all common antibiotics. In most cases, PNECs for selection of resistance were below available PNECs for ecotoxicological effects. The generated PNECs can guide implementation of compound-specific emission limits that take into account risks for resistance promotion.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Geovetenskap och miljövetenskap ->
Miljövetenskap ->
Miljökemi ->
Miljötoxikologi
NATURVETENSKAP ->
Biologiska vetenskaper ->
Mikrobiologi
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området ->
Mikrobiologi ->
Bakteriologi
Nyckelord:
Antibiotic resistance, Emission limits, Minimal selective concentrations, Predicted no effect concentrations, Good manufacturing practice, Environmental risk assessment
Postens nummer:
227344
Posten skapad:
2015-12-05 22:11
Posten ändrad:
2016-04-28 15:45

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