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Göteborgs universitets publikationer

Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.

Författare och institution:
Stephanie A Schultz (-); Elizabeth A Boots (-); Rodrigo P Almeida (-); Jennifer M Oh (-); Jean Einerson (-); Claudia E Korcarz (-); Dorothy F Edwards (-); Rebecca L Koscik (-); Maritza N Dowling (-); Catherine L Gallagher (-); Barbara B Bendlin (-); Bradley T Christian (-); Henrik Zetterberg (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Kaj Blennow (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Cynthia M Carlsson (-); Sanjay Asthana (-); Bruce P Hermann (-); Mark A Sager (-); Sterling C Johnson (-); James H Stein (-); Ozioma C Okonkwo (-)
Publicerad i:
Journal of the International Neuropsychological Society : JINS, 21 ( 10 ) s. 841-50
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer's disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer's Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C Pittsburgh Compound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples, from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning & Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (p<.001) and Verbal Learning & Memory (p<.001). Specifically, in the context of high Aβ burden, that is, increased PiB-PET binding or reduced CSF Aβ42, individuals with higher CRF exhibited significantly better cognition compared with individuals with lower CRF. In a late-middle-aged, at-risk cohort, higher CRF is associated with a diminution of Aβ-related effects on cognition. These findings suggest that exercise might play an important role in the prevention of AD. (JINS, 2015, 21, 841-850).
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Neurovetenskaper ->
Postens nummer:
Posten skapad:
2015-12-03 18:01
Posten ändrad:
2016-01-15 09:11

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