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Göteborgs universitets publikationer

The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents.

Författare och institution:
Daniel Vallöf (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Paola Maccioni (-); Giancarlo Colombo (-); Minja Mandrapa (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Julia Winsa Jörnulf (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Emil Egecioglu (-); Jörgen Engel (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Elisabeth Jerlhag (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi)
Publicerad i:
Addiction Biology, 21 ( 2 ) s. 422–437
ISSN:
1355-6215
E-ISSN:
1369-1600
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide treatment suppressed the well-documented effects of alcohol on the mesolimbic dopamine system, namely alcohol-induced accumbal dopamine release and conditioned place preference in mice. In addition, acute administration of liraglutide prevented the alcohol deprivation effect and reduced alcohol intake in outbred rats, while repeated treatment of liraglutide decreased alcohol intake in outbred rats as well as reduced operant self-administration of alcohol in selectively bred Sardinian alcohol-preferring rats. Collectively, these data suggest that GLP-1 receptor agonists could be tested for treatment of alcohol dependence in humans.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Farmakologi och toxikologi ->
Farmakologi
Nyckelord:
Addictive behaviours;dependence;reward
Postens nummer:
226893
Posten skapad:
2015-12-02 13:34
Posten ändrad:
2016-08-23 15:13

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