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Göteborgs universitets publikationer

Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia

Författare och institution:
Björn Regland (Institutionen för neurovetenskap och fysiologi); Sara Forsmark (Institutionen för neurovetenskap och fysiologi); Lena Halaouate (Institutionen för neurovetenskap och fysiologi); Markus Matousek (Institutionen för neurovetenskap och fysiologi); Birgitta Peilot (Institutionen för neurovetenskap och fysiologi); Olof Zachrisson (Institutionen för neurovetenskap och fysiologi); Carl-Gerhard Gottfries (Institutionen för neurovetenskap och fysiologi)
Publicerad i:
PLoS ONE, 10 ( 4 )
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: Patients with myalgic encephalomyelitis (ME, also called chronic fatigue syndrome) may respond most favorably to frequent vitamin B12 injections, in vital combination with oral folic acid. However, there is no established algorithm for individualized optimal dosages, and rate of improvement may differ considerably between responders. Objective: To evaluate clinical data from patients with ME, with or without fibromyalgia, who had been on B12 injections at least once a week for six months and up to several years. Methods: 38 patients were included in a cross-sectional survey. Based on a validated observer's rating scale, they were divided into Good (n = 15) and Mild (n = 23) responders, and the two groups were compared from various clinical aspects. Results: Good responders had used significantly more frequent injections (p<0.03) and higher doses of B12 (p<0.03) for a longer time (p<0.0005), higher daily amounts of oral folic acid (p<0.003) in good relation with the individual MTHFR genotype, more often thyroid hormones (p<0.02), and no strong analgesics at all, while 70% of Mild responders (p<0.0005) used analgesics such as opioids, duloxetine or pregabalin on a daily basis. In addition to ME, the higher number of patients with fibromyalgia among Mild responders was bordering on significance (p<0.09). Good responders rated themselves as "very much" or "much" improved, while Mild responders rated "much" or "minimally" improved. Conclusions: Dose-response relationship and long-lasting effects of B12/folic acid support a true positive response in the studied group of patients with ME/fibromyalgia. It's important to be alert on co-existing thyroid dysfunction, and we suspect a risk of counteracting interference between B12/folic acid and certain opioid analgesics and other drugs that have to be demethylated as part of their metabolism. These issues should be considered when controlled trials for ME and fibromyalgia are to be designed. © 2015 Regland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Postens nummer:
Posten skapad:
2015-11-30 16:14
Posten ändrad:
2015-11-30 16:17

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