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Göteborgs universitets publikationer

Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and -Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level

Författare och institution:
L. Walther (-); Andrea deBejczy (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Elin Löf (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); T. Hansson (-); A. Andersson (-); J. Guterstam (-); A. Hammarberg (-); G. Asanovska (-); J. Franck (-); Bo Söderpalm (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); A. Isaksson (-)
Publicerad i:
Alcoholism-Clinical and Experimental Research, 39 ( 11 ) s. 2200-2208
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BackgroundIn clinical practice as well as research situations, it is of great importance to get reliable information about a patient's alcohol consumption. The aim of the study was to investigate the correlation of alcohol biomarkers (phosphatidylethanol [PEth], carbohydrate-deficient transferrin [CDT], -glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase) to retrospective as well as diary-based alcohol self-reports and to examine whether it is possible to correlate a biomarker result to a more precise level of alcohol consumption. MethodsOne hundred and sixty alcohol-dependent patients were included in a randomized, placebo-controlled clinical trial of pharmacotherapy for alcohol dependence, of which 115 (76 men and 39 women) completed the study. Retrospective alcohol consumption data were collected at baseline, and alcohol diaries were used during the study. Blood samples for determination of alcohol biomarkers were collected on 5 occasions during the study. ResultsPEth and CDT showed a better correlation with alcohol consumption documented in the diary (PEth r(s)=0.56 and CDT r(s)=0.35) than with retrospective consumption data (PEth r(s)=0.23 and CDT r(s)=0.22). An even higher correlation (r(s)=0.63) was seen between the 2 alcohol biomarkers PEth and CDT. At all consumption levels, PEth had the highest sensitivity of all biomarkers studied. ConclusionsPEth was the biomarker with the best correlation to self-reported alcohol consumption. PEth was superior to CDT owing to its substantially higher sensitivity but also due to its closer correlation to self-report. PEth values can be translated into an approximate level of alcohol consumption and PEth appears to be a more reliable measure of alcohol consumption than self-reports.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Alcohol Biomarker, Phosphatidylethanol, Carbohydrate-Deficient Transferrin, Reported Alcohol, direct ethanol metabolites, liver-disease, biomarker, phosphatidylethanol, blood phosphatidylethanol, healthy-volunteers, mass-spectrometry, rat organs, audit-c, drinking, peth, Substance Abuse
Postens nummer:
Posten skapad:
2015-11-20 11:07

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