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Göteborgs universitets publikationer

Botulinum toxin A injections and occupational therapy in children with unilateral spastic cerebral palsy: a randomized controlled trial

Författare och institution:
Git Lidman (Institutionen för neurovetenskap och fysiologi); Alf Nachemson (-); Marie Peny-Dahlstrand (Institutionen för neurovetenskap och fysiologi); Kate Himmelmann (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik)
Publicerad i:
Developmental Medicine and Child Neurology, 57 ( 8 ) s. 754-761
ISSN:
0012-1622
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
AimTo investigate the effects of repeated botulinum toxin A (BoNT-A) injections combined with occupational therapy, including a splint, compared with occupational therapy alone on hand function in children with unilateral spastic cerebral palsy (USCP), in all International Classification of Functioning, Disability and Health (ICF) domains. MethodThis was a randomized controlled study, population-based and evaluator-blinded for primary outcome (October 2004 to September 2010). Twenty children (14 males; median age 3y 1mo) with USCP, recruited at a rehabilitation centre in Sweden, were assigned to one of two parallel groups using concealed allocation. In the course of one year, 10 children received occupational therapy, while 10 received repeated BoNT-A plus occupational therapy (BoNT-A/OT). Primary outcome (Assisting Hand Assessment [AHA]), and secondary outcome measures (range of movement [ROM], and Canadian Occupational Performance Measure), were measured at baseline, 3, 6, 9, and 12months. ResultsAHA revealed a superior effect in the BoNT-A/OT group at 12months: 6 out of 10 improved compared with 1 out of 10 in the occupational therapy group (p<0.03). A 95% Peskun exact confidence interval for the difference in proportions is given as 0.01 to 0.81. Secondary outcomes improved in both groups. InterpretationRepeated BoNT-A/OT appeared superior to occupational therapy alone for bimanual performance in young children with USCP. Active ROM and goal performance improved in both groups.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Neurologi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Pediatrik
Nyckelord:
ASSISTING HAND ASSESSMENT, INDUCED MOVEMENT THERAPY, UPPER-LIMB, RELIABILITY, HEMIPLEGIA, OUTCOMES, Clinical Neurology, Pediatrics
Postens nummer:
220320
Posten skapad:
2015-08-07 11:09
Posten ändrad:
2016-05-04 13:18

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