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Göteborgs universitets publikationer

Impacts of enterotoxin gene cluster-encoded superantigens on local and systemic experimental Staphylococcus aureus infections

Författare och institution:
Forough Nowrouzian (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Abukar Ali (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); C. Badiou (-); O. Dauwalder (-); G. Lina (-); Elisabet Josefsson (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
European Journal of Clinical Microbiology & Infectious Diseases, 34 ( 7 ) s. 1443-1449
ISSN:
0934-9723
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Staphylococcus aureus is both a component of the normal skin flora and an important pathogen. It expresses a range of recognized and putative virulence factors, such as enterotoxins with superantigenic properties. Several superantigen genes, i.e., seg, sei, selm, seln, and selo, are encoded by the enterotoxin gene cluster (egc), which is found in the majority of S. aureus isolates. Carriage of egc is associated with fitness of S. aureus in the gut microbiota, but it is not known if it contributes to pathogenicity. We constructed egc+ (functional for the seg, selm, and selo genes) and isogenic egc- S. aureus mutants, and investigated their virulence profiles in murine infection models. No effect of egc was seen in a local skin and soft tissue infection model, but in an invasive infection model, increased weight loss was observed after infection with the egc+ as compared to the egc- mutant. Mortality and arthritis were not affected by egc status. Our data suggest that egc has limited effects on the virulence of S. aureus. It may primarily function as a colonization factor increasing commensal fitness, although it might have some aggravating effects on the infection when the bacteria reach the blood. DELNOUR A, 1994, EUROPEAN JOURNAL OF IMMUNOLOGY, V24, P1161 DELNOUR A, 1994, JOURNAL OF INFECTIOUS DISEASES, V170, P94
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Nyckelord:
T-CELL-RECEPTOR, VIRULENCE, EXPRESSION, STRAINS, SHOCK, MICE, EGC, COLONIZATION, POLYMORPHISM, PREVALENCE, Infectious Diseases, Microbiology
Postens nummer:
219701
Posten skapad:
2015-07-10 13:47
Posten ändrad:
2016-08-30 11:47

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