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Göteborgs universitets publikationer

Explorative study on quality of life in relation to salivary secretion rate in head and neck cancer patients treated with radiotherapy.

Författare och institution:
Annica Almståhl (Institutionen för odontologi & Institutionen för odontologi, sektion 3); Torgny Alstad (Institutionen för odontologi & Institutionen för odontologi, sektion 3); Bodil Fagerberg-Mohlin (Institutionen för odontologi); Anette Carlén (Institutionen för odontologi, sektion 3); Caterina Finizia (Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för öron-, näs- och halssjukdomar)
Publicerad i:
Head & neck, 38 ( 5 ) s. 782-791
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: Radiation therapy (RT) to the head and neck (H&N) region often results in oral complications. In this explorative study, the pretreatment and posttreatment (6 months and 12 months) quality of life (QoL) was analysed for patients with H&N cancer. The associations between QoL and salivary secretion rates were analysed. Methods: In 29 patients (19 men and 10 women, mean age 59±8 years), the stimulated whole salivary secretion and buccal minor gland secretion were measured. The patients completed the European Organisation for Research and Treatment of Cancer Quality of Life questionnaires (QLQ-C30 and H&N35) and the Hospital Anxiety and Depression scale (HADS). Results: One year after the completion of radiotherapy, subjects with hyposalivation (≤ 0.7 ml/min) reported clinically meaningful, but not statistically significant differences, in cognitive functioning, insomnia, swallowing, social eating, dry mouth, sticky saliva and use of painkillers. Statistically significant differences were found for emotional functioning, sticky saliva and dyspnea (p<0.05). Thirtythree percent of them had a HADS score suggesting anxiety problems compared to 8% for those with whole stimulated salivary secretion rates > 0.7 ml/min. Conclusion: Radiotherapy in the H&N region, also using intensity-modulated radiotherapy, is associated with many aspects of life such as cognitive functioning, insomnia, dry mouth and sticky saliva, especially for those with hyposalivation. This article is protected by copyright. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Cancer och onkologi
quality of life;radiation therapy;cancer;saliva;minor gland saliva
Postens nummer:
Posten skapad:
2015-04-09 14:18
Posten ändrad:
2016-04-28 15:42

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