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Göteborgs universitets publikationer

The effect of exercise on angiogenic factors in the healthy mouse heart: A short report

Författare och institution:
Christina Karazisi (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Aron Onerup (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Pia Larsson (Wallenberglaboratoriet); Lena M S Carlsson (Wallenberglaboratoriet); Mats Börjesson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Smita DuttaRoy (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Experimental and Clinical Cardiology, 20 ( 1 ) s. 2332-2341
Artikel, refereegranskad vetenskaplig
Pulsus Group Inc.
Sammanfattning (abstract):
Background: Exercise increases blood levels of crucial angiogenic factors and endothelial progenitor cells (EPCs). Hypoxia inducible factor-1 (HIF-1a) and vascular endothelial growth factor (VEGF) are also increased in skeletal muscle in response to exercise. In the healthy heart, voluntary exercise is not expected to cause local hypoxia. We studied how voluntary exercise affects cardiac expression of HIF-1a, VEGF and stromal derived factor-1 (SDF-1), as well as EPC levels in heart and skeletal muscle. Method: Thirty-two NMRI mice were randomized to exercise in running wheels (EX) or regular activity (SED). HIF-1a, VEGF and SDF-1 mRNA levels were analyzed by reverse transcription polymerase chain reaction (RT-PCR) and EPC levels in heart and hind limb were quantified by FACS after 7 and 14 days. Results: There was no significant difference in cardiac expression of HIF-1a, VEGF or SDF-1 between EX and SED. Cardiac EPC levels were not affected by exercise, while skeletal EPC level was more than doubled. Conclusion: Voluntary exercise does not seem to induce cardiac hypoxia or stimulate the angiogenic system. In the healthy normoxic heart, there is a limited need of supporting blood supply, which might explain these findings.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Endothelial progenitor cells, Exercise, Heart, angiogenic factor, hypoxia inducible factor 1alpha, messenger RNA, stromal cell derived factor 1, vasculotropin, angiogenesis, animal experiment, animal tissue, article, cardiovascular effect, cardiovascular risk, controlled study, coronary artery blood flow, endothelial progenitor cell, female, fluorescence activated cell sorting, heart muscle, hindlimb, hypoxia, mouse, muscle growth, NMRI mouse, nonhuman, protein expression, reverse transcription polymerase chain reaction, sedentary lifestyle, sitting, treadmill exercise
Postens nummer:
Posten skapad:
2015-03-16 14:41
Posten ändrad:
2016-06-10 13:41

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