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Göteborgs universitets publikationer

Composition of Human Peri-implantitis and Periodontitis Lesions

Författare och institution:
Olivier Carcuac (Institutionen för odontologi); Tord Berglundh (Institutionen för odontologi)
Publicerad i:
Journal of Dental Research, 93 ( 11 ) s. 1083-1088
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The aim of the present study was to examine differences in cellular characteristics of human peri-implantitis and periodontitis lesions. Two groups of patients were included: 40 patients with generalized severe chronic periodontitis and 40 patients presenting with severe peri-implantitis. Soft tissue biopsies were obtained from diseased sites (probing pocket depth 7 mm with bleeding on probing) and prepared for histologic and immunohistochemical analysis. In contrast to periodontitis samples, peri-implantitis lesions were more than twice as large and contained significantly larger area proportions, numbers, and densities of CD138-, CD68-, and MPO-positive cells than periodontitis lesions. Peri-implantitis lesions also extended to a position that was apical of the pocket epithelium and not surrounded by noninfiltrated connective tissue. They further presented with significantly larger densities of vascular structures in the connective tissue area lateral to the infiltrated connective tissue than within the infiltrate. This study suggests that peri-implantitis and periodontitis lesions exhibit critical histopathologic differences, which contribute to the understanding of dissimilarities in onset and progression between the 2 diseases.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Odontologi ->
Kirurgisk forskning
biopsy, dental implant, immunohistochemistry, inflammation, inflammatory cell, peri-implant disease, IMMUNOHISTOCHEMICAL CHARACTERISTICS, EUROPEAN WORKSHOP, CONSENSUS, DISEASES, TISSUES, Dentistry, Oral Surgery & Medicine
Postens nummer:
Posten skapad:
2014-12-05 09:36

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