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Göteborgs universitets publikationer

Disposable microfluidic chip with integrated light sheet illumination enables diagnostics based on membrane vesicles

Författare och institution:
H. Deschout (-); K. Raemdonck (-); S. Stremersch (-); P. Maoddi (-); G. Mernier (-); P. Renaud (-); S. Jiguet (-); A. Hendrix (-); M. Bracke (-); R. Van den Broecke (-); Magnus Röding (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU & SuMo Biomaterials, Chalmers); Mats Rudemo (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU); J. Demeester (-); S. De Smedt (-); F. Strubbe (-); K. Neyts (-); K. Braeckmans (-)
Publicerad i:
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Freiburg; Germany; 27 October 2013 through 31 October 2013, 3 s. 2010-2012
ISBN:
978-16-32-66624-6
Publikationstyp:
Konferensbidrag, refereegranskat
Publiceringsår:
2014
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Cell-derived membrane vesicles that are released in body fluids are emerging as potential non-invasive biomarkers for diseases like cancer. Techniques capable of measuring the size and concentration of such membrane vesicles directly in body fluids are urgently needed. Here we report on a microfluidic chip with integrated light sheet illumination, and demonstrate accurate fluorescence Single Particle Tracking measurements of the size and concentration of membrane vesicles in cell culture medium and in interstitial fluid collected from primary human breast tumours.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Biologiska vetenskaper ->
Biokemi och molekylärbiologi ->
Biokemi
Nyckelord:
Diagnostics; Lab-on-a-chip; Light sheet microscopy; Single Particle Tracking
Postens nummer:
203905
Posten skapad:
2014-10-08 08:43
Posten ändrad:
2016-05-10 16:20

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