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Göteborgs universitets publikationer

The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy

Författare och institution:
D. Bi (-); M. J. Chen (-); X. L. Zhang (-); H. L. Wang (-); L. Xia (-); Q. Shang (-); T. C. Li (-); D. N. Zhu (-); Klas Blomgren (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering); L. He (-); Xiaoyang Wang (Institutionen för neurovetenskap och fysiologi); Q. H. Xing (-); Changlian Zhu (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering)
Publicerad i:
Journal of Neuroinflammation, 11
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: The relationship between genetic factors and the development of cerebral palsy (CP) has recently attracted much attention. Polymorphisms in the genes encoding proinflammatory cytokines have been shown to be associated with susceptibility to perinatal brain injury and development of CP. Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a pivotal role in neonatal brain injury, but conflicting results have been reported regarding the association between IL-6 single nucleotide polymorphisms (SNPs) and CP. The purpose of this study was to analyze IL-6 gene polymorphisms and protein expression and to explore the role of IL-6 in the Chinese CP population. Methods: A total of 753 healthy controls and 713 CP patients were studied to detect the presence of five SNPs (rs1800796, rs2069837, rs2066992, rs2069840, and rs10242595) in the IL-6 locus. Of these, 77 healthy controls and 87 CP patients were selected for measurement of plasma IL-6 by Luminex assay. The SHEsis program was used to analyze the genotyping data. For all comparisons; multiple testing on each individual SNP was corrected by the SNPSpD program. Results: There were no differences in allele or genotype frequencies between the overall CP patients and controls among the five genetic polymorphisms. However, subgroup analysis found significant sex-related differences in allele and genotype frequencies. Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837. Plasma IL-6 levels were higher in CP patients than in the controls, and this difference was more robust in full-term male spastic CP patients. Furthermore, the genotype has an effect on IL-6 synthesis. Conclusions: The influence of IL-6 gene polymorphisms on IL-6 synthesis and the susceptibility to CP is related to sex and gestational age.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Neurovetenskaper ->
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Cytokine, Inflammation, Periventricular leukomalacia, Single nucleotide polymorphisms, PRETERM PREMATURE RUPTURE, CHILDREN BORN, PROMOTER POLYMORPHISMS, GESTATIONAL-AGE, ISCHEMIC-STROKE, INFANTS, BIRTH, TERM, SUSCEPTIBILITY, INFLAMMATION, Immunology, Neurosciences
Postens nummer:
Posten skapad:
2014-08-05 14:24

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