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Göteborgs universitets publikationer

Platelet proteins as autoantibody targets in idiopathic thrombocytopenic purpura.

Författare och institution:
Hans Wadenvik (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Dick Stockelberg (Institutionen för invärtesmedicin, Avdelningen för internmedicin); M Hou (Institutionen för invärtesmedicin, Avdelningen för internmedicin)
Publicerad i:
Acta paediatrica (Oslo, Norway : 1992). Supplement, 424 s. 26-36
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Idiopathic thrombocytopenic purpura (ITP), caused by autoantibodies directed against certain platelet antigens, is the most common entity of the immune thrombocytopenias. ITP is an acquired disorder and can affect both children and adults. However, the clinical syndromes of ITP are distinct between children and adults. Childhood (acute) ITP characteristically is acute in onset, occurs within 1-2 weeks of an infection, usually of viral origin, resolves spontaneously within 6 months. Adult (chronic) ITP has an insidious onset and rarely resolves spontaneously. Over the last decade considerable new information has accumulated as to the pathophysiological mechanisms of immune thrombocytopenias. In addition, most of the knowledge on this disorder has been obtained from studies of adult patients with chronic ITP. The present work gives an updated overview of the platelet autoantigens and the molecular immunological reactions in ITP.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Acute Disease, Adult, Antigens, CD31, Antigens, CD36, Autoantibodies, immunology, Blood Platelets, immunology, Child, Chronic Disease, Humans, Immunity, Cellular, immunology, Immunoglobulin G, immunology, Platelet Glycoprotein GPIIb-IIIa Complex, Platelet Glycoprotein GPIb-IX Complex, Platelet Membrane Glycoproteins, Purpura, Thrombocytopenic, Idiopathic, immunology, physiopathology, virology, Receptors, Cell Surface, Tropomyosin, immunology
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Posten skapad:
2014-05-09 16:20

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