transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Sensitization to airborne allergens among adults and its impact on allergic symptoms: a population survey in northern Vietnam

Författare och institution:
Hoàng T Lâm (-); Linda Ekerljung (Krefting Research Centre); Anders Bjerg (Krefting Research Centre); Nguyễn Văn Tường (-); Bo Lundbäck (Krefting Research Centre); Eva Rönmark (-)
Publicerad i:
Clinical and Translational Allergy. 2014 Feb 10;4(1):6, 4 ( 6 )
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Abstract Background The knowledge about allergic sensitization and its relationship with clinical symptoms and diseases among adults in South-East Asia is poor. The aim of this study was to investigate the prevalence and pattern of allergic sensitization and the association with asthma and allergic rhinitis in adults in urban and rural Vietnam. Methods Among 5,782 responders to a questionnaire survey in northern Vietnam, a random sample was invited to a clinical follow-up and 684 (46%) participated. The methods included a structured interview using a modified GA2LEN study questionnaire on symptoms and possible determinants for diseases. Skin prick test (SPT) with ten common airborne indoor and outdoor allergens, lung function test, and methacholine test was performed among subjects ≤60 years of age. Results In total, one third of subjects had a positive SPT reaction to at least one allergen, 36.9% of men and 31.0% of women (n.s.). The most common sensitizer was the storage mite B. tropicalis (men 27.7%; women 18.7%) followed by house dust mite D. pteronyssinus (men 16.5%; women 10.6%), and D. farinae (men 15.3%; women 6.3%), and cockroach (men 16.5%; women 10.2%). Sensitization to all major allergens were significantly more common among men and among subjects ≤45 years compared with women and subjects >45 years, respectively. The prevalence of sensitization to animals, pollen and molds were low. The majority of cockroach-sensitized subjects were also sensitized to mites. Sensitization to any allergen and all major allergens were significantly associated with rhinitis, but not with asthma. However, bronchial hyper-reactivity was significantly associated with increasing number of positive SPTs (p = 0.047). Conclusions Among adults in northern Vietnam sensitization to mite and cockroach most common in both rural and urban areas. The dominant sensitizer was the storage mite B. tropicalis, which should be included in future studies and also in clinical practice, owing to its association with clinical symptoms. As in the Western world allergic sensitization was associated with rhinitis and bronchial hyper-reactivity. The lack of association with asthma in South-East Asia needs to be studied further.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Postens nummer:
Posten skapad:
2014-03-10 13:30

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007