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Göteborgs universitets publikationer

Human C-tactile afferents are tuned to the temperature of a skin-stroking caress

Författare och institution:
Rochelle Ackerley (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Helena Backlund Wasling (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Jaquette Liljencrantz (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Håkan Olausson (-); Richard D. Johnson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Johan Wessberg (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
Journal of Neuroscience, 34 ( 8 ) s. 2879-2883
Artikel, refereegranskad vetenskaplig
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
Human C-tactile (CT) afferents respond vigorously to gentle skin stroking and have gained attention for their importance in social touch. Pharmacogenetic activation of the mouse CT equivalent has positively reinforcing, anxiolytic effects, suggesting a role in grooming and affiliative behavior. We recorded from single CT axons in human participants, using the technique of microneurography, and stimulated a unit's receptive field using a novel, computer-controlled moving probe, which stroked the skin of the forearm over five velocities (0.3, 1, 3, 10, and 30 cm s-1) at three temperatures (cool, 18°C; neutral, 32°C; warm, 42°C). We show that CTs are unique among mechanoreceptive afferents: they discharged preferentially to slowly moving stimuli at a neutral (typical skin) temperature, rather than at the cooler or warmer stimulus temperatures. In contrast, myelinated hair mechanoreceptive afferents proportionally increased their firing frequency with stroking velocity and showed no temperature modulation. Furthermore, the CT firing frequency correlated with hedonic ratings to the same mechano-thermal stimulus only at the neutral stimulus temperature, where the stimuli were felt as pleasant at higher firing rates. We conclude that CT afferents are tuned to respond to tactile stimuli with the specific characteristics of a gentle caress delivered at typical skin temperature. This provides a peripheral mechanism for signaling pleasant skin-to-skin contact in humans, which promotes interpersonal touch and affiliative behavior. © 2014 the authors.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
C-fiber, Human, Low-threshold mechanoreceptor, Somatosensory, Thermal, Touch
Postens nummer:
Posten skapad:
2014-03-05 12:29
Posten ändrad:
2014-04-16 14:46

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