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Changes in medication preceding out-of-hospital cardiac arrest where resuscitation was attempted.

Författare och institution:
Christina M Holmgren (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); N J Abdon (-); Lennart Bergfeldt (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Nils Edvardsson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); J D Herlitz (-); Thomas Karlsson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); L G Svensson (-); B H Astrand (-)
Publicerad i:
Journal of cardiovascular pharmacology, 68 ( 6 ) s. 497-503
ISSN:
1533-4023
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2014
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Objective: To describe recent changes in medication preceding Out-of-Hospital Cardiac Arrest (OHCA) where resuscitation was attempted. Methods: OHCA victims were identified by the Swedish Cardiac Arrest Register and linked by means of their unique 10-digit personal identification numbers to the Prescribed Drug Register. We identified new claimed prescriptions during a six month period prior to the OHCA compared with those claimed 12-18 months before. The 7-digit ATC codes of individual drugs were used. The study period was November 2007 to January 2011 Results: OHCA victims with drugs were older than those who did not claim any drugs in any period (70±16years vs. 54±22 years p<0.001), were more often women (34% vs. 20%, p<0.001) and had more often a presumed cardiac etiology (67% vs. 54% (p<0.001), were less likely to have VT/VF as the first recorded rhythm (26% vs. 33%, p<0.001) or to survive one month (9% vs. 17%, p<0.0001).New prescriptions were claimed by 5122 (71%) of 7243 OHCA victims. The most frequently claimed new drugs were paracetamol (acetaminophen) 10.3%, furosemide 7.8% and omeprazole 7.6%. Of drugs known or supposed to cause QT prolongation, ciprofloxacin was the most frequent (3.4%) altogether; 16% had a new claimed prescription of a drug included in the ¨qtdrugs.org¨ lists. Conclusion: A majority of OHCA victims had new drugs prescribed
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kardiologi ->
Kardiovaskulär medicin
Nyckelord:
Out-of-Hospital Cardiac Arrest (OHCA); QT prolongation; medication; torsade de pointes; proarrhythmia
Postens nummer:
193396
Posten skapad:
2014-02-04 11:32
Posten ändrad:
2016-08-25 09:42

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