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Göteborgs universitets publikationer

Pneumococcal vaccine responses in elderly patients with multiple myeloma, Waldenstrom’s macroglobulinemia, and monoclonal gammopathy of undetermined significance

Författare och institution:
Johanna Karlsson (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition & Institutionen för biomedicin, avdelningen för infektionssjukdomar); Harriet Hogevik (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Kerstin Andersson (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Leyla Roshani (-); Björn Andréasson (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Christine Wennerås (Institutionen för biomedicin, avdelningen för infektionssjukdomar & Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition)
Publicerad i:
Trials in vaccinology, 2 s. 31-38
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background Vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV) has been recommended for elderly patients with B cell malignancies and dysfunctions because of their enhanced susceptibility to pneumococcal infections. More recent recommendations advocate the use of conjugate pneumococcal vaccines. Methods We compared responses to single dose vaccination with either PPV or the 7-valent pneumococcal conjugate vaccine (PCV7) in fifty-six patients ⩾60 years with a diagnosis of multiple myeloma (n = 24), Waldenstrom’s macroglobulinemia (n = 15) and the non-malignant B cell disorder monoclonal gammopathy of undetermined significance (MGUS) (n = 17), and 20 age-matched controls. Serum was collected prior to vaccination and 4–8 weeks later, and analyzed for IgG antibody levels to pneumococcal serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F by ELISA. Functional antibody activity towards pneumococcal serotypes 4 and 14 was measured using an opsonophagocytic killing assay (OPA). Results All patient groups had lower pre-vaccination IgG antibody and OPA titers to the investigated serotypes compared to the healthy controls. Following vaccination, myeloma patients responded with significant IgG titer increases to 1/7 serotypes and OPA titer increases to 1/2 serotypes. Corresponding IgG and OPA vaccine responses were 3/7 and 0/2 for Waldenstrom patients, 4/7 and 1/2 for MGUS patients, and 4/7 and 2/2 for the healthy controls, respectively. Notably high antibody levels without corresponding OPA titers were seen among a few myeloma patients indicating the presence of non-functional antibodies. Neither of the two vaccines elicited significantly higher serotype-specific IgG concentrations, OPA titers or antibody fold increases in any of the study groups. Hypogammaglobulinemia and ongoing chemotherapy were associated with poor vaccine responses in a multivariate analysis. Conclusion Our findings confirm that B cell malignancies and disorders among elderly patients are associated with suboptimal responses to pneumococcal vaccination. Single-dose PCV7 was not shown to be superior to PPV.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper ->
Klinisk medicin ->
Klinisk medicin ->
Immunitet, multipelt myelom, Waldenströms makroglobulinemi, monoklonala gammopatier, pneumokockvaccination, antikroppar
Postens nummer:
Posten skapad:
2014-01-07 14:01
Posten ändrad:
2014-05-28 16:22

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