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Göteborgs universitets publikationer

Acute vascular effects of atorvastatin in hypertensive men: a pilot study.

Författare och institution:
Ott Saluveer (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Niklas Bergh (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Ludger Grote (-); Ove Andersson (-); Thordis Hrafnkelsdottir (Wallenberglaboratoriet); Bengt R Widgren (-)
Publicerad i:
Scandinavian cardiovascular journal : SCJ, 47 ( 5 ) s. 275-80
ISSN:
1651-2006
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2013
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Abstract Objectives. Statins have multiple pleiotropic effects that are independent of their cholesterol-lowering properties including rapid improvement of endothelial function in vitro. Hypertension is characterized by endothelial dysfunction and we hypothesized that a single-dose of atorvastatin may have an acute effect on vascular function. Design. Endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation were assessed with venous occlusion plethysmography during intra-arterial infusion of acetylcholine (ACH) and sodium nitroprusside (SNP), respectively, in 13 hypertensive men after wash-out from antihypertensive medication. Vasoconstrictive responses were evaluated in response to angiotensin II (Ang II) infusion. The protocol was repeated 1 h after 80 mg oral atorvastatin (ATV; Lipitor(®)). Results. ATV treatment significantly increased baseline forearm blood flow from 3.38 (0.27) to 4.31 (0.35) ml/min/100 ml tissue (p < 0.05). ATV did not affect ACH-induced EDV. Forearm vascular resistance in response to SNP was significantly lowered by ATV (p < 0.05). Vasoconstriction in response to Ang II was significantly inhibited by ATV treatment (p = 0.005). Conclusions. The observed acute statin effects in hypertension appear to be endothelium-independent and related to vascular smooth muscle cell function. These actions may in part contribute to the beneficial pleiotropic effects of statin therapy even in the acute in vivo setting.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kardiologi ->
Kardiovaskulär medicin
Postens nummer:
184217
Posten skapad:
2013-09-30 10:46
Posten ändrad:
2016-08-24 14:03

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