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Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial.

Författare och institution:
Christopher Gillberg (Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri); Hans Melander (-); Anne-Liis von Knorring (-); Lars-Olof Janols (-); Gunilla Thernlund (-); Bruno Hägglöf (-); Lena Eidevall-Wallin (-); Peik Gustafsson (-); Svenny Kopp (Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri)
Publicerad i:
Archives of general psychiatry, 54 ( 9 ) s. 857-864
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: We wanted to study the effects of amphetamine on symptoms of attention-deficit hyperactivity disorder (ADHD) over a longer period than has been reported in previous studies of central stimulants in this condition. Methods: Sixty-two children, aged 6 to 11 years, meeting DSM-III-R symptom criteria for ADHD participated in a parallel-group design, randomized, double-blind, placebo-controlled study of amphetamine treatment. Treatment was not restricted to children with "pure" ADHD, ie, some had comorbid diagnoses. In the amphetamine group, children received active treatment for 15 months. Results: Amphetamine was clearly superior to placebo in reducing inattention, hyperactivity, and other disruptive behavior problems and tended to lead to improved results on the Wechsler Intelligence Scale for Children—Revised. Treatment failure rate was considerably lower and time to treatment failure was longer in the amphetamine group. Adverse effects were few and relatively mild. Conclusion: The results of this long-term, placebo-controlled study of the central stimulant amphetamine in the treatment of ADHD indicate that there are remaining positive effects of the drug 15 months after starting treatment.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Psykiatri ->
Barn- och ungdomspsykiatri
Abdominal Pain, chemically induced, epidemiology, Amphetamine, adverse effects, therapeutic use, Attention Deficit Disorder with Hyperactivity, drug therapy, psychology, Bipolar Disorder, chemically induced, epidemiology, Central Nervous System Stimulants, adverse effects, therapeutic use, Child, Comorbidity, Double-Blind Method, Female, Follow-Up Studies, Headache, chemically induced, epidemiology, Humans, Male, Placebos, Sleep Disorders, chemically induced, epidemiology, Treatment Outcome, Wechsler Scales
Postens nummer:
Posten skapad:
2013-09-02 11:50

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