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Göteborgs universitets publikationer

Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat.

Författare och institution:
Jakob Näslund (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Erik Studer (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Karin Nilsson (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Lars Westberg (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Elias Eriksson (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi)
Publicerad i:
Psychopharmacology, 230 ( 1 ) s. 29-35
ISSN:
1432-2072
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2013
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
BACKGROUND: Numerous studies suggest (1) that a major physiological role of brain serotonin-containing neurons is to modulate sex steroid-driven behaviour such as sex and aggression, (2) that sex steroids influence brain serotonergic neurotransmission and (3) that brain serotonergic neurotransmission displays sexual dimorphism. Such observations indicate that an important task for brain serotonin is to either enhance or counteract sex differences in behaviour. METHODS: To test this hypothesis, we explored the effect of short-term serotonin depletion on the behaviour of adult male and female rats in a behavioural paradigm in which males and females have been shown to behave differently, i.e. the elevated plus maze. RESULTS: Two rounds of testing of untreated Wistar rats confirmed the previous observation that females make more entries into open arms (round 1, p = 0.001; round 2, p = 0.008) and spend more time on these arms (round 1, p ≤ 0.001; round 2, p = 0.006) than males; in addition, males displayed fewer entries into closed arms upon habituation, i.e. at the second round (p ≤ 0.001) than did females. Administration of the tryptophan hydroxylase inhibitor para-chloro-phenylalanine, at a regimen (300 mg/kg/day for 3 days), markedly reducing brain content of serotonin, enhanced entries upon open arms (p = 0.01) and time spent on open arms (p = 0.004) in males but exerted no such effects in females (p = 0.9 and p = 0.9, respectively); moreover, it reduced entries into closed arms in females (p ≤ 0.001) but not in males (p = 0.1). CONCLUSIONS: Serotonin depletion abolishing the sex differences observed at baseline supports the theory that serotonin aids to uphold certain sex differences in behaviour.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Farmakologi och toxikologi ->
Farmakologi
Nyckelord:
Serotonin depletion, sex differences, anxiety-related behaviour
Postens nummer:
181373
Posten skapad:
2013-08-14 13:41
Posten ändrad:
2016-08-09 09:12

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