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Göteborgs universitets publikationer

Effects of Endothelin Receptor Antagonists on Renal Hemodynamics in Angiotensin II-Infused Rats on High NaCl Intake

Författare och institution:
Aso Saeed (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); G. F. DiBona (-); Gregor Guron (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Kidney & Blood Pressure Research, 36 ( 1 ) s. 258-267
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Aim: The aim was to investigate effects of selective endothelin (ET) receptor antagonists on renal hemodynamics and dynamic renal blood flow autoregulation (RBFA) in angiotensin II (Ang II)-infused rats on a high NaCl intake. Methods: Sprague-Dawley rats received Ang II (250 ng/kg/min, s.c.) and an 8 % NaCl diet for 14 days after which renal clearance experiments were performed. After baseline measurements animals were administered either: (a) saline vehicle; (b) ETA receptor antagonist BQ-123 (30 nmol/kg/min); (c) ETB receptor antagonist BQ-788 (30 nmol/kg/min); or (d) BQ-123 + BQ-788, for six consecutive 20-minute clearance periods. Results: BQ-123 reduced arterial pressure (AP) and selectively increased outer medullary perfusion versus vehicle (p<0.05). These effects were attenuated or abolished by combined BQ-123 and BQ-788. BQ-788 reduced renal blood flow and increased renovascular resistance (p<0.05). Ang II-infused rats on high NaCl intake showed abnormalities in dynamic RBFA characterized by an impaired myogenic response that were not significantly affected by ET receptor antagonists. Conclusion: In hypertensive Ang II-infused rats on a high-NaCl intake selective ETA antagonism with BQ-123 reduced AP and specifically increased OM perfusion and these effects were dependent on intact ETB receptor stimulation. Furthermore, ET receptor antagonists did not attenuate abnormalities in dynamic RBFA
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Angiotensin II, Endothelin, Renal blood flow, Renal autoregulation, Renal medullary blood flow, peripheral vascular-resistance, salt-sensitive hypertension, duct-specific knockout, blood-flow, collecting duct, etb receptors, sodium retention, healthy-men, arterial-pressure, oxygen-tension
Postens nummer:
Posten skapad:
2013-07-10 11:18

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