transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Inhibitory inputs to four types of spinocerebellar tract neurons in the cat spinal cord.

Författare och institution:
B A Bannatyne (-); S Shakya Shrestha (-); Elzbieta Jankowska (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Ingela Hammar (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Elin Nilsson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); D J Maxwell (-)
Publicerad i:
Neuroscience, 226 s. 253-69
Artikel, refereegranskad vetenskaplig
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition of motoneurons and on the operation of inhibitory premotor neurons. Our aim was to extend previous comparisons of morphological substrates of excitation of spinocerebellar neurons to inhibitory input. Contacts formed by inhibitory axon terminals were characterised as either GABAergic, glycinergic or both GABAergic/glycinergic by using antibodies against vesicular GABA transporter, glutamic acid decarboxylase and gephyrin. Quantitative analysis revealed the presence of much higher proportions of inhibitory contacts when compared with excitatory contacts on spinal border (SB) neurons. However similar proportions of inhibitory and excitatory contacts were associated with ventral spinocerebellar tract (VSCT) and dorsal spinocerebellar tract neurons located in Clarke's column (ccDSCT) and the dorsal horn (dhDSCT). In all of the cells, the majority of inhibitory terminals were glycinergic. The density of contacts was higher on somata and proximal versus distal dendrites of SB and VSCT neurons but more evenly distributed in ccDSCT and dhDSCT neurons. Variations in the density and distribution of inhibitory contacts found in this study may reflect differences in information on inhibitory processes forwarded by subtypes of spinocerebellar tract neurons to the cerebellum.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Neurovetenskaper ->
Animals, Cats, Electric Stimulation, Glutamic Acid, physiology, Glycine, physiology, Image Processing, Computer-Assisted, Immunohistochemistry, Microscopy, Confocal, Nerve Endings, physiology, Neurons, physiology, Peripheral Nerves, physiology, Spinal Cord, physiology, Spinocerebellar Tracts, physiology, Vesicular Glutamate Transport Protein 1, physiology, Vesicular Glutamate Transport Protein 2, physiology, Vesicular Inhibitory Amino Acid Transport Proteins, physiology, gamma-Aminobutyric Acid, physiology
Postens nummer:
Posten skapad:
2013-07-02 07:30
Posten ändrad:
2014-11-25 12:28

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007