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Göteborgs universitets publikationer

Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and unknown?

Författare och institution:
Ruijin Shao (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Junting Hu (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Yi Feng (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Håkan Billig (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
International Journal of Clinical and Experimental Pathology, 6 ( 4 ) s. 810-815
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
More than 98% of ectopic pregnancies occur in the Fallopian tube. Because many facets of tubal ectopic pregnancy remain unclear, prediction, prevention and treatment of tubal ectopic pregnancy are still a major clinical challenge. Compelling evidence suggests that angiogenic growth factors are involved in normal and abnormal implantation. While acknowledging the importance of an intrauterine pregnancy requires the development of a local blood supply and angiogenesis, we hypothesize that the hypoxic- and estrogen-dependent regulation of vascular endothelial growth factor/placental growth factor expression, secretion, and signaling pathways that are possibly involved in the pathophysiology of tubal ectopic pregnancy. Our hypothesis may also lead to a new therapeutic strategy for women with tubal ectopic pregnancy.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
VEGF, VEGF receptor, fallopian tube, ectopic pregnancy, oviductal epithelial-cells, messenger-rna expression, tyrosine kinase-1, secretion, stromal fibroblasts, intrauterine pregnancy, fallopian-tube, factor vegf, in-vitro, estrogen, mechanisms
Postens nummer:
Posten skapad:
2013-06-27 12:24

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