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Göteborgs universitets publikationer

VIP-antiserum inhibits fluid secretion by the inflamed gallbladder mucosa.

Författare och institution:
Bengt E Nilsson (Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi); E Theodorsson (-); Lennart Jivegård (Institutionen för de kirurgiska disciplinerna); Anders Thune (-); Styrbjörn Friman (Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi); Joar Svanvik (Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi)
Publicerad i:
Regulatory peptides, 49 ( 3 ) s. 179-84
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The inflammatory fluid secretion by the gallbladder mucosa in experimental cholecystitis is induced by an increased prostaglandin formation and is mediated by intramural nerves. In the present study the effect of VIP-antiserum on the inflammatory fluid secretion in the gallbladder was tested in a validated experimental model in cats. The animals were studied in acute experiments 6 weeks after a procedure when the cystic duct was tied and gallstones were implanted in the gallbladder. During basal conditions there was a continuous secretion of fluid into the lumen of the inflamed gallbladder averaging 0.43 +/- 0.18 ml/h. Injection of VIP antiserum, obtained from immunized rabbits and diluted with saline 1:10 in a bolus of 4 ml into the coeliac artery reversed this secretion into an absorption of 1.72 +/- 0.44 ml h-1 (P < 0.001). VIP-antiserum did not affect the fluid adsorption in control animals with an intact gallbladder and injection of control serum from rabbits not immunized to VIP did not affect fluid secretion in the inflamed gallbladders. The results support the idea that the inflammatory fluid secretion in the gallbladder mucosa is mediated by VIP-ergic nerve fibres.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Animals, Bile, secretion, Cats, Cholecystitis, metabolism, Disease Models, Animal, Exudates and Transudates, secretion, Female, Gallbladder, secretion, Immune Sera, pharmacology, Male, Mucous Membrane, secretion, Rabbits, Vasoactive Intestinal Peptide, immunology, physiology
Postens nummer:
Posten skapad:
2013-06-20 09:35

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