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Göteborgs universitets publikationer

Instability of repolarization in LQTS mutation carriers compared to healthy control subjects assessed by vectorcardiography.

Författare och institution:
Farzad Vahedi (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Ulla-Britt Diamant (-); Gunilla Lundahl (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Gabriel Bergqvist (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Lennart Gransberg (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Steen M Jensen (-); Lennart Bergfeldt (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Heart rhythm : the official journal of the Heart Rhythm Society, 10 ( 8 ) s. 1169-75
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Potassium channel dysfunction in congenital and acquired forms of long QT syndromes type 1 and 2 (LQT1, LQT2) increases the beat to beat variability of the QT interval. OBJECTIVES: Little is, however, known about the variability (instability) of other aspects of ventricular repolarization (VR) in humans and was therefore the topic of this study applying vectorcardiography (VCG). METHODS: Beat to beat analysis was performed regarding VCG derived RR, QRS and QT intervals, as well as T vector and T vector loop based parameters during one minute recordings of uninterrupted sinus rhythm at rest in 41 adult LQT1 (n=31) and LQT2 (n=10) mutation carriers and 41 age and sex matched control subjects. The short-term variability (STV) for each parameter, describing the mean orthogonal distance to the line of identity on the Poincaré plot, was calculated. RESULTS: Mutation carriers showed significantly larger (by a factor 2) instability in most VR parameters compared to controls despite higher instantaneous heart rate variability (STVRR) in the control group. The longer the QT interval, the greater was its instability and the instability of VR dispersion measures Tarea (global dispersion) and ventricular gradient (action potential morphology dispersion). CONCLUSION: A greater instability of most aspects of VR already at rest seems to be a salient feature in both LQT1 and LQT2, which might pave the way for early afterdepolarizations and Torsades de Pointes ventricular tachycardia. In contrast, no signs of increased VR dispersion per se were observed in the mutation carriers.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Kardiologi ->
Kardiovaskulär medicin
Postens nummer:
Posten skapad:
2013-06-17 14:12
Posten ändrad:
2013-08-21 13:41

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