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Göteborgs universitets publikationer

In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate

Författare och institution:
Hanne Evenbratt (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi, Chalmers); Charlotte A Jonsson (Institutionen för kemi och molekylärbiologi); Jan Faergemann (-); Sven Engström (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi, Chalmers); Marica B Ericson (Institutionen för kemi och molekylärbiologi & Institutionen för fysik (GU))
Publicerad i:
International Journal of Pharmaceutics, 452 ( 1-2 ) s. 270-275
ISSN:
0378-5173
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2013
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
We demonstrate a rapidly formed cubic liquid crystalline phase, i.e. typically 1 g cubic phase in less than 1 min confirmed by X-ray diffraction, consisting of an ether lipid, 1-glyceryl monooleyl ether (GME), an aprotic solvent (propylene glycol or pentane-1,5-diol) and water. The efficacy of the cubic formulation was tested in vivo by administrating formulations containing 3% (w/w) of the HCl salts of delta-aminolevulinic acid (ALA) or methylaminolevulinate (MAL) to hairless mice. The endogenous formation of protoporphyrin IX (PpIX) was monitored spectrophotometrically as a marker for cellular uptake of active compound. As reference, a commercial product containing 16% (w/w) MAL in an oil-in-water emulsion (Metvix (R)), and a cubic phase based on an ester lipid (glyceryl monooleate, GMO), previously shown to facilitate topical delivery of both ALA and MAL, were applied. It was found that in general the cubic phases gave rise to higher fluorescence levels than the mice exposed to the commercial product. The instantly formed cubic formulations based on GME demonstrated the same efficiency as the GMO based formulations. The results imply that instantly formed cubic formulations opens up new opportunities, particularly for transdermal drug delivery of substances subject to stability problems in, e. g. aqueous environments.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Kemi ->
Annan kemi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Dermatologi och venereologi
Nyckelord:
Instantly formed cubic phase; Topical delivery;Glyceryl monooleyl ether, Glyceryl monooleate, Aminolevulinic acid, Methylaminolevulinate
Postens nummer:
178264
Ingår i post nr:
Posten skapad:
2013-06-11 15:29
Posten ändrad:
2016-07-07 16:04

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