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Göteborgs universitets publikationer

Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome

Författare och institution:
Anna Benrick (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Manuel Maliqueo (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Miao Sun (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); J. A. Villanueva (-); Y. Feng (-); Claes Ohlsson (Centre for Bone and Arthritis Research & Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); A. J. Duleba (-); Elisabet Stener-Victorin (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
Evidence-Based Complementary and Alternative Medicine, s. Article ID 964070
Artikel, refereegranskad vetenskaplig
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with obesity and insulin resistance that often precedes the development of type-2 diabetes. Rats continuously exposed to dihydrotestosterone from prepuberty display typical reproductive and metabolic PCOS characteristics including anovulation, polycystic ovaries, insulin resistance, and obesity. Our aim was to investigate if resveratrol improves reproductive and metabolic functions in PCOS rats. The effect was compared to exercise. Control and PCOS rats were treated with vehicle or resveratrol (400 mg · kg−1 · day−1) for 5-6 weeks. Another group of PCOS rats received vehicle treatment and exercised for 5-6 weeks. Insulin sensitivity was determined by euglycemic-hyperinsulinemic clamp. The glucose infusion rate was lower in the PCOS-vehicle group compared to control-vehicle rats (). Exercise increased insulin sensitivity compared with PCOS-vehicle rats (), but resveratrol did not. Resveratrol treatment and exercise resulted in smaller adipocytes, upregulated estrogen-related receptor α gene expression in subcutaneous fat, and improved estrus cyclicity in the previously acyclic PCOS rats. Although resveratrol had positive effects on adiposity and cyclicity in a similar manner to exercise, resveratrol does not seem to be a good candidate for treating insulin resistance associated with PCOS because no improvement in insulin sensitivity was observed in PCOS rats on normal chow.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
low-frequency electroacupuncture, sympathetic-nerve activity, theca-interstitial cells, adipose-tissue, skeletal-muscle, adipocyte, size, in-vitro, diet, women, fat
Postens nummer:
Posten skapad:
2013-05-29 08:57
Posten ändrad:
2013-08-12 10:44

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