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Göteborgs universitets publikationer

Acupuncture for ovulation induction in polycystic ovary syndrome: A randomized controlled trial.

Författare och institution:
Julia Johansson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Leanne Redman (-); Paula P Veldhuis (-); Antonina Sazonova (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi); Fernand Labrie (-); Göran Holm (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Gudmundur Johannsson (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Elisabet Stener-Victorin (Institutionen för neurovetenskap och fysiologi)
Publicerad i:
American journal of physiology. Endocrinology and metabolism, 304 ( 9 ) s. E934-E943
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Acupuncture has been demonstrated to improve menstrual frequency and to decrease circulating testosterone in women with polycystic ovary syndrome (PCOS). Our aim was to investigate whether acupuncture affects ovulation frequency and to understand the underlying mechanisms of any such effect by analyzing luteinizing hormone (LH) and sex steroid secretion in women with PCOS. This prospective, randomized, controlled clinical trial was conducted between June 2009 and September 2010. Thirty-two women with PCOS were randomized to receive either acupuncture in combination with manual and low-frequency electrical stimulation or to meetings with a physical therapist twice a week for 10-13 weeks. Main outcome measures were changes in LH secretion patterns from baseline to after 10-13 weeks of treatment and ovulation frequency during the treatment period. Secondary outcomes were changes in the secretion of sex steroids, anti-Müllerian hormone, inhibin B, and serum cortisol. Ovulation frequency during treatment was higher in the acupuncture group compared with the control group. After 10-13 weeks of intervention, circulating levels of estrone, estrone sulfate, estradiol, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, testosterone, free-testosterone, dihydrotestosterone, androsterone glucuronide, androstane-3α, 17β-diol-3glucuronide, and androstane-3α, 17β-diol-17glucuronide decreased within the acupuncture group and were significantly lower than in the control group for all of these except androstenedione. We conclude that repeated acupuncture treatments resulted in higher ovulation frequency in lean/overweight women with PCOS and were more effective than just meeting with the therapist. Ovarian and adrenal sex steroid serum levels were reduced with no effect on LH secretion.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Reproduktionsmedicin och gynekologi
Postens nummer:
Posten skapad:
2013-05-27 10:03
Posten ändrad:
2016-08-25 08:41

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