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Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome.

Författare och institution:
Wei Shi (-); Xiao-Yu Kong (-); Zhong-Ming Wang (-); Shan-Shan Yu (-); Hai-Xia Chen (Institutionen för biologi och miljövetenskap); Elizabeth A De Stasio (-)
Publicerad i:
BMC genomics, 14 ( 1 ) s. 103
Artikel, refereegranskad vetenskaplig
Fulltextlänk (lokalt arkiv):
Sammanfattning (abstract):
ABSTRACT: BACKGROUND: Tandem repeats (TRs) in the mitochondrial (mt) genome control region have been documented in a wide variety of vertebrate species. The mechanism by which repeated tracts originate and undergo duplication and deletion, however, remains unclear. RESULTS: We analyzed DNA sequences of mt genome TRs (mtTRs) in the ridged-eye flounder (Pleuronichthys cornutus), and characterized DNA sequences of mtTRs from other vertebrates using the data available in GenBank. Tandem repeats are concentrated in the control regions; however, we found approximately 16.6% of the TRs elsewhere in the mt genome. The flounder mtTRs possess three motif types with hypervariable characteristics at the 3[prime] end of the control region (CR). CONCLUSION: Based on our analysis of this larger dataset of mtTR sequences, we propose a novel model of Pause Melting Misalignment (PMM) to describe the birth and motif indel of tandem repeats. PMM is activated during a pause event in mitochondrial replication in which a dynamic competition between the nascent (N) heavy strand and the displaced (D) heavy strand may lead to the melting of the N-strand from the template (T) light strand. When mispairing occurs during rebinding of the N-strand, one or several motifs can be inserted or deleted in both strands during the next round of mt-replication or repair. This model can explain the characteristics of TRs in available vertebrate mt genomes.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper
Ytterligare information:
© 2013 Shi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Shi et al. BMC Genomics 2013, 14 :103
Postens nummer:
Posten skapad:
2013-03-18 15:11
Posten ändrad:
2013-03-18 15:12

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