transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Cinnamyl alcohol oxidizes rapidly upon air exposure

Författare och institution:
Ida B Niklasson (Institutionen för kemi och molekylärbiologi); Tamara Delaine (Institutionen för kemi och molekylärbiologi); Islam Nurul (Institutionen för kemi och molekylärbiologi); Roger Karlsson (Institutionen för kemi och molekylärbiologi); Kristina Luthman (Institutionen för kemi och molekylärbiologi); Ann-Therese Karlberg (Institutionen för kemi och molekylärbiologi)
Publicerad i:
Contact Dermatitis, 68 ( 3 ) s. 129-138
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background. Cinnamyl alcohol and cinnamal are frequent fragrance contact allergens. Both are included in the European baseline fragrance mix I, which is used for screening of contact allergy in dermatitis patients. Objectives. The aim of this study was to investigate the autoxidation of cinnamyl alcoholandtoidentifytheoxidationproductsformedonairexposure.Wealsowantedto evaluate the effect of autoxidation on the sensitization potency of cinnamyl alcohol. Methods. Samples of commercially available cinnamyl alcohol with and without purificationwereexposedtoair,andtheautoxidationwasfollowedbychemicalanalysis. Theanalysiswasperformedwithmassspectrometry(LC/MS/MS).Sensitizationpotencies ofcompoundsweredeterminedwiththemurinelocallymphnodeassay(LLNA)inmice. Results. Chemical analysis showed that the concentration of cinnamyl alcohol in the air-exposed samples decreased rapidly over time, and that autoxidation products were formed. Cinnamal, epoxy cinnamyl alcohol and cinnamic acid were identified as oxidation products. According to our study, cinnamal and epoxy cinnamyl alcohol were thefirstautoxidation productsformed. Theepoxy cinnamyl alcohol wasshowntobethe oxidation product with the highest sensitization potency. The analysis of our samples of commercially available cinnamyl alcohol showed that there was already a content of 1.5% cinnamal at the start of the autoxidation experiments. Conclusion. Cinnamylalcoholreadilyautoxidizesuponairexposure,andformsstrong sensitizers as determined by the LLNA. Cinnamal was formed in the largest amounts, showingthatcinnamalisnotonlyformedviabioactivation,ashaspreviouslybeenshown. A highly sensitizing epoxide was also identified and quantified in the oxidation mixture.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Kemi ->
Organisk kemi
Postens nummer:
Posten skapad:
2013-03-07 09:08
Posten ändrad:
2013-03-07 12:58

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007