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Isolated hepatic perfusion with extracorporeal oxygenation using hyperthermia TNF alpha and melphalan: Swedish experience.

Författare och institution:
Lars-Olof Hafström (Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi); Peter Naredi (-)
Publicerad i:
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, 147 s. 120-6
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
A phase I trial was performed to determine the toxicity and efficacy of isolated hepatic perfusion with tumour necrosis factor alpha (TNF) and melphalan (Alkeran) under mild hyperthermic conditions. Eleven patients with unresectable metastatic malignancies in the liver (malignant melanoma, leiomyosarcoma, colorectal cancer) underwent the procedure. Compared to our earlier experience with melphalan and cis-platinum under hyperthermic conditions (41.7 degrees C), this phase I study with TNF 30-200 micrograms and melphalan ).5 mg/kg body weight under 39 degrees C hyperthermia neither improved the response rate nor decreased the serious adverse effects. Two patients died within the first postoperative month owing to coagulopathy or multiple organ failure. Five patients were reoperated owing to postoperative bleeding. Three of six patients with liver metastases from malignant melanoma or leiomyosarcoma and none of five patients with liver metastases from colorectal cancer showed a partial response.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Cancer och onkologi
Antineoplastic Agents, Alkylating, administration & dosage, therapeutic use, Chemotherapy, Cancer, Regional Perfusion, methods, Extracorporeal Membrane Oxygenation, Humans, Hyperthermia, Induced, Liver Neoplasms, drug therapy, mortality, secondary, Melphalan, administration & dosage, therapeutic use, Survival Rate, Sweden, Treatment Outcome, Tumor Necrosis Factor-alpha, administration & dosage, therapeutic use
Postens nummer:
Posten skapad:
2013-02-13 09:09

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