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Göteborgs universitets publikationer

Self-Glycolipids Modulate Dendritic Cells Changing the Cytokine Profiles of Committed Autoreactive T Cells

Författare och institution:
K. Buschard (-); Jan-Eric Månsson (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); B. O. Roep (-); T. Nikolic (-)
Publicerad i:
Plos One, 7 ( 12 )
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The impact of glycolipids of non-mammalian origin on autoimmune inflammation has become widely recognized. Here we report that the naturally occurring mammalian glycolipids, sulfatide and beta-GalCer, affect the differentiation and the quality of antigen presentation by monocyte-derived dendritic cells (DCs). In response to sulfatide and beta-GalCer, monocytes develop into immature DCs with higher expression of HLA-DR and CD86 but lower expression of CD80, CD40 and CD1a and lower production of IL-12 compared to non-modulated DCs. Self-glycolipid-modulated DCs responded to lipopolysaccharide (LPS) by changing phenotype but preserved low IL-12 production. Sulfatide, in particular, reduced the capacity of DCs to stimulate autoreactive Glutamic Acid Decarboxylase (GAD65) - specific T cell response and promoted IL-10 production by the GAD65-specific clone. Since sulfatide and beta-GalCer induced toll-like receptor (TLR)-mediated signaling, we hypothesize that self-glycolipids deliver a (tolerogenic) polarizing signal to differentiating DCs, facilitating the maintenance of self-tolerance under proinflammatory conditions.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Annan naturvetenskap
dependent diabetes-mellitus, ii nkt cells, beta-cells, insulin epitope, nod mice, sulfatide, galactosylceramide, prevents, autoimmunity, pathogenesis
Postens nummer:
Posten skapad:
2013-01-25 15:18

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