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Göteborgs universitets publikationer

Ghrelin Influences Novelty Seeking Behavior in Rodents and Men

Författare och institution:
Caroline Hansson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi & Institutionen för medicin); Rozita H. Shirazi (Institutionen för neurovetenskap och fysiologi); Jakob Näslund (Institutionen för neurovetenskap och fysiologi); Heike Vogel (Institutionen för neurovetenskap och fysiologi); Corinna Neuber (Institutionen för medicin); Göran Holm (Institutionen för medicin); Henrik Anckarsäter (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Suzanne L. Dickson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Elias Eriksson (Institutionen för neurovetenskap och fysiologi); Karolina P Skibicka (Institutionen för neurovetenskap och fysiologi)
Publicerad i:
Plos One, 7 ( 12 )
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Recent discoveries indicate an important role for ghrelin in drug and alcohol reward and an ability of ghrelin to regulate mesolimbic dopamine activity. The role of dopamine in novelty seeking, and the association between this trait and drug and alcohol abuse, led us to hypothesize that ghrelin may influence novelty seeking behavior. To test this possibility we applied several complementary rodent models of novelty seeking behavior, i.e. inescapable novelty-induced locomotor activity (NILA), novelty-induced place preference and novel object exploration, in rats subjected to acute ghrelin receptor (growth hormone secretagogue receptor; GHSR) stimulation or blockade. Furthermore we assessed the possible association between polymorphisms in the genes encoding ghrelin and GHSR and novelty seeking behavior in humans. The rodent studies indicate an important role for ghrelin in a wide range of novelty seeking behaviors. Ghrelin-injected rats exhibited a higher preference for a novel environment and increased novel object exploration. Conversely, those with GHSR blockade drastically reduced their preference for a novel environment and displayed decreased NILA. Importantly, the mesolimbic ventral tegmental area selective GHSR blockade was sufficient to reduce the NILA response indicating that the mesolimbic GHSRs might play an important role in the observed novelty responses. Moreover, in untreated animals, a striking positive correlation between NILA and sucrose reward behavior was detected. Two GHSR single nucleotide polymorphisms (SNPs), rs2948694 and rs495225, were significantly associated with the personality trait novelty seeking, as assessed using the Temperament and Character Inventory (TCI), in human subjects. This study provides the first evidence for a role of ghrelin in novelty seeking behavior in animals and humans, and also points to an association between food reward and novelty seeking in rodents. Citation: Hansson C, Shirazi RH, Naslund J, Vogel H, Neuber C, et al. (2012) Ghrelin Influences Novelty Seeking Behavior in Rodents and Men. PLoS ONE 7(12): e50409. doi:10.1371/journal.pone.0050409
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Annan naturvetenskap
Postens nummer:
Posten skapad:
2013-01-25 15:16
Posten ändrad:
2016-08-09 09:14

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