transparent gif


Ej inloggad.

Göteborgs universitets publikationer

The anticaries effect of a food extract (shiitake) in a short-term clinical study.

Författare och institution:
Peter Lingström (Institutionen för odontologi); Egija Zaura (-); Haidar Hassan (Institutionen för odontologi); Mark J Buijs (-); Pamie Hedelin (Institutionen för odontologi); Jonathan Pratten (-); David Spratt (-); Maria Daglia (-); Aneta Karbowiak (-); Caterina Signoretto (-); Martijn Rosema (-); Fridus van der Weijden (-); Michael Wilson (-)
Publicerad i:
Journal of biomedicine & biotechnology, 2012 s. 217164
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The main objective was to investigate whether low-molecular-weight fraction of edible mushroom shiitake extract (Lentinus edodes) possesses caries-preventive properties. The study was designed as a double-blind, three-leg, cross-over, randomized, controlled clinical trial carried out on two series of volunteers at the University of Gothenburg, and the Academic Centre for Dentistry Amsterdam. Volunteers rinsed twice daily with a solution containing low-molecular-weight fraction of edible mushroom, placebo (negative control without active ingredients), or Meridol (positive control, AmF-SnF(2)) for two weeks, with a two-week washout period between each rinsing period. Changes in the acidogenicity of dental plaque before and after a sucrose challenge, shifts in microbial composition, and plaque scores were determined. Frequent rinses with shiitake reduced the metabolic activity of dental plaque. No reduction of plaque scores and no inhibition of the production of organic acids in plaque was found. Minor differences in microbial composition between test sessions were found. To conclude, the results indicate that shiitake extract has anticariogenic potential, but not to the same extent as the positive control.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Odontologi ->
Adult, Amines, administration & dosage, Analysis of Variance, Bacteria, drug effects, Biofilms, drug effects, Cariostatic Agents, pharmacology, Dental Plaque, chemistry, drug therapy, microbiology, Double-Blind Method, Drug Combinations, Female, Humans, Hydrogen-Ion Concentration, Male, Mouthwashes, administration & dosage, chemistry, Questionnaires, Saliva, drug effects, microbiology, Shiitake Mushrooms, chemistry, Sucrose, Tin Fluorides, administration & dosage
Postens nummer:
Posten skapad:
2013-01-17 18:58

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007