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Göteborgs universitets publikationer

Six months of high-dose xylitol in high-risk caries subjects-a 2-year randomised, clinical trial.

Författare och institution:
Guglielmo Campus (-); Maria Grazia Cagetti (-); Silvana Sale (-); Massimo Petruzzi (-); Giuliana Solinas (-); Laura Strohmenger (-); Peter Lingström (Institutionen för odontologi)
Publicerad i:
Clinical oral investigations, 17 ( 3 ) s. 785-791
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVES: The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces (ΔD(6)S) in high-risk schoolchildren after 2 years. METHODS: In this randomised, clinical trial, 204 schoolchildren with a high caries risk were assigned to two experimental groups, xylitol and non-xylitol. Caries status, salivary mutans streptococci, and lactobacilli were re-evaluated 2 years later in 74 xylitol-treated and 83 non-xylitol-treated schoolchildren. Differences in mean ∆D(6)S between groups registered at baseline and at follow-up were evaluated using the nonparametric Mann-Whitney U test. RESULTS: Outcome was the development of detectable carious lesions initial (D(1)-D(2)) and manifest (D(3)) in the permanent first molars. In the xylitol group, the difference in proportion of children with decayed first permanent molars at baseline and follow-up was 1.43 % for manifest lesion and 2.86 % for initial lesions; while in the non-xylitol group was 10.26 % (p < 0.01) and 16.66 % (p < 0.01), respectively. A statistically significant difference regarding means was also observed in the non-xylitol group: the ∆D(6)S for manifest lesion was 0.18 (p = 0.03) and 0.67 (p = 0.02) for initial lesion. CONCLUSION: The use of a chewing gum containing a high dose of xylitol for a period of 6 months has been shown to produce a long-term effect on caries development in high caries-risk children. CLINICAL RELEVANCE: A school-based preventive programme based on 6 months' administration of a high dose of xylitol via chewing gum proved to be efficacious in controlling caries increment in high-risk children.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Odontologi ->
xylitol, caries, clinical trial, bacteria
Postens nummer:
Posten skapad:
2013-01-17 18:46
Posten ändrad:
2013-04-26 10:44

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