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Göteborgs universitets publikationer

Enveloped virus but not bacteria block IL-13 responses in human cord blood T cells in vitro.

Författare och institution:
Alexandra Svensson (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Inger Nordström (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Anna Rudin (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Tomas Bergström (-); Kristina Eriksson (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Scandinavian journal of immunology, 75 ( 4 ) s. 409-18
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Infections that occur early in life may have a beneficial effect on the immune system and thereby reduce the risk of allergen sensitization and/or allergic disease. It is not yet clear to what extent specific virus and/or bacteria can mediate this effect. The purpose of this study was to assess the role of virus and bacteria in CD4(+) T cell-derived cytokine production in newborns. We compared the effects of five bacteria (Staphlococcus aureus, Escherichia coli, Clostridium difficile, Lactobacillus rhamnosus and Bifidobacterium bifidus) and seven virus (adenovirus, coronavirus, cytomegalovirus, herpes simplex virus, influenza virus, morbillivirus and poliovirus) on the Th1/Th2 cytokine production in mixed lymphocyte reactions using CD4(+) T cells from cord blood cocultured with allogenic myeloid or plasmacytoid dendritic cells. When comparing the baseline cytokine production prior to microbial stimulation, we observed that cord plasmacytoid DC were stronger inducers of Th2 cytokines (IL-5 and IL-13) compared with cord myeloid DC and to adult DC. When adding microbes to these cultures, bacteria and virus differed in two major respects; Firstly, all enveloped viruses, but none of the bacteria, blocked Th2 (IL-13) production by cord CD4(+) cells. Secondly, all Gram-positive bacteria, but none of the virus, induced IL-12p40 responses, but the IL-12p40 responses did not affect Th1 cytokine production (IFN-γ). Instead, Th1 responses were correlated with the capacity to induce IFN-α secretion, which in cord cells were induced by S. aureus and influenza virus alone. These data imply that enveloped virus can deviate Th2 responses in human cord T cells.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Klinisk medicin ->
Cells, Cultured, DNA Viruses, immunology, Fetal Blood, immunology, Gram-Positive Bacteria, immunology, Humans, Interleukin-13, immunology, secretion, RNA Viruses, immunology, T-Lymphocytes, immunology, secretion, Viral Envelope Proteins, immunology
Postens nummer:
Posten skapad:
2012-12-18 11:29
Posten ändrad:
2013-01-08 10:48

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