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Göteborgs universitets publikationer

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections.

Författare och institution:
Jan Jessen Krut (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Henrik Zetterberg (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Kaj Blennow (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Paola Cinque (-); Lars Hagberg (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Richard W Price (-); Marie Studahl (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Magnus Gisslén (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
Journal of neurology, 230 s. 620-626
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The cerebrospinal fluid (CSF) biomarker profile in Alzheimer's disease (AD) is characterized by decreased beta amyloid (Aβ(1-42)), increased total and hyperphosphorylated tau (t-tau and p-tau, respectively), which is a useful diagnostic tool and gives insight in the pathogenesis of AD. It is of importance to study how these biomarkers react in other CNS diseases; therefore, we decided to analyse amyloid and tau biomarkers in different CNS infections. We also included analysis of soluble amyloid precursor proteins (sAPPα and -β). CSF Aβ(1-42), sAPPα and -β, t-tau and p-tau were analysed in bacterial meningitis (n = 12), Lyme neuroborreliosis (n = 13), herpes simplex virus type 1 (HSV-1) encephalitis (n = 10), HIV-associated dementia (HAD) (n = 21), AD (n = 21) and healthy controls (n = 42). Concurrent with AD, Aβ(1-42) was decreased in all groups except neuroborreliosis compared to controls. HSV-1 encephalitis, bacterial meningitis and HAD showed lower concentrations of sAPPα and -β compared to AD. T-tau was increased in AD and HSV-1 encephalitis compared to all other groups. P-tau was higher in AD and HSV-1 encephalitis compared to bacterial meningitis, HAD and control. Decreased CSF Aβ(1-42), sAPPα and -β in various CNS infections imply an effect of neuroinflammation on amyloid metabolism which is similar in regard to AD concerning Aβ(1-42), but differs concerning sAPPα and -β. These results clearly indicate different pathologic pathways in AD and infectious CNS disease and may provide help in the differential biomarker diagnostics. Increased p-tau in HSV-1 encephalitis probably reflect acute neuronal damage and necrosis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Bacterial infections, Central nervous system, Herpes encephalitis, HIV-associated dementia (MesH term AIDS dementia complex), Amyloid Tau protein
Postens nummer:
Posten skapad:
2012-10-12 10:58
Posten ändrad:
2013-04-03 16:10

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