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Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. Focus on Obesity, Diet and Alcohol Intake.

Författare och institution:
Gianluca Tognon (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Christina Berg (Institutionen för kost- och idrottsvetenskap); Kirsten Mehlig (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Dag Thelle (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Elisabeth Strandhagen (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Jaana Gustavsson (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Annika Rosengren (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Lauren Lissner (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa)
Publicerad i:
PloS one, 7 ( 7 ) s. e40878
ISSN:
1932-6203
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2012
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The ratio between apolipoprotein B and apolipoprotein A-I (apoB/apoA-I) has been suggested to be a powerful and more accurate predictor of future cardiovascular disease risk than total cholesterol and HDL cholesterol. Since diet and lifestyle can directly influence dyslipidemia, it is of interest to identify modifiable factors that are associated with high levels of the apolipoprotein ratio and if they can have a different association with a more traditional indicator of cardiovascular risk such as total cholesterol/HDL. The relationship between obesity and dyslipidemia is established and it is of interest to determine which factors can modify this association. This study investigated the cross-sectional association of obesity, diet and lifestyle factors with apoB/apoA-I and total cholesterol/HDL respectively, in a Swedish population of 2,907 subjects (1,537 women) as part of the INTERGENE study. The apolipoprotein and lipoprotein ratios were highly correlated, particularly in women, and obesity was strongly associated with both. Additionally, age, cigarette smoking and alcohol intake were important determinants of these ratios. Alcohol was the only dietary factor that appreciably attenuated the association between obesity and each of the ratios, with a stronger attenuation in women. Other dietary intake and lifestyle-related factors such as smoking status and physical activity had a lower effect on this association. Because the apolipoprotein and lipoprotein ratios share similar diet and lifestyle determinants as well as being highly correlated, we conclude that either of these ratios may be a sufficient indicator of dyslipidemia.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper ->
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper ->
Näringslära
Postens nummer:
161279
Posten skapad:
2012-08-08 21:15
Posten ändrad:
2016-06-10 11:24

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