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Göteborgs universitets publikationer

On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis.

Författare och institution:
Teresa Lagergård (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Ingrid Bölin (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Leif Lindholm (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi)
Publicerad i:
Annals of the New York Academy of Sciences, 1230 s. E1-E10
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Haemophilus ducreyi and Klebsiella (Calymmatobacterium) granulomatis are sexually transmitted bacteria that cause characteristic, persisting ulceration on external genitals called chancroid and granuloma inguinale, respectively. Those ulcers are endemic in developing countries or exist, as does granuloma inguinale, only in some geographic "hot spots."H. ducreyi is placed in the genus Haemophilus (family Pasteurellacae); however, this phylogenetic position is not obvious. The multiple ways in which the bacterium may be adapted to its econiche through specialized nutrient acquisitions; defenses against the immune system; and virulence factors that increase attachment, fitness, and persistence within genital tissue are discussed below. The analysis of K. granulomatis phylogeny demonstrated a high degree of identity with other Klebsiella species, and the name K. granulomatis comb. nov. was proposed. Because of the difficulty in growing this bacterium on artificial media, its characteristics have not been sufficiently defined. More studies are needed to understand bacterial genetics related to the pathogenesis and evolution of K. granulomatis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Animals, Chancroid, genetics, microbiology, transmission, Evolution, Molecular, Genetic Variation, Haemophilus ducreyi, genetics, pathogenicity, physiology, Humans, Klebsiella, genetics, pathogenicity, physiology, Klebsiella Infections, genetics, microbiology, transmission, Phylogeny, Sexually Transmitted Diseases, Bacterial, microbiology, Virulence Factors, genetics, physiology
Postens nummer:
Posten skapad:
2012-06-14 12:54

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