A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits
Författare och institution:
M. Wiig (-); Kjell Olmarker (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); J. Hakansson (-); Lars Ekström (Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för ortopedi); Elin Nilsson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Margit Mahlapuu (-)
Publicerad i:
J Hand Surg Eur Vol, 36 ( 8 ) s. 656-62
ISSN:
2043-6289
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2011
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Injuries to flexor tendons can lead to loss of finger function after healing due to adhesion formation. The aim of this study was to assess the efficacy and safety of the new peptide, PXL01, in the prevention of peritendinous adhesions. The effect of a single intraoperative administration of PXL01 in sodium hyaluronate on mobility of the affected digit after surgery was assessed in a rabbit model by measuring total active motion, metatarsophalangeal-claw distance and resistance to bending the digits. Load-to-failure testing was done in the same specimens to assess tendon healing. The results demonstrated that a single application of PXL01 in sodium hyaluronate significantly improved mobility of the treated digits compared with the digits in which the same surgery was carried out but no treatment was provided. No negative effects on tendon healing were observed in connection with the treatment.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kirurgi ->
Ortopedi
Klinisk medicin ->
Kirurgi ->
Ortopedi
Nyckelord:
Animals, Biomechanics, Carrier Proteins/ pharmacology, Disease Models, Animal, Female, Hindlimb, Hyaluronic Acid/ pharmacology, Hydrogels, Lactoferrin/ pharmacology, Postoperative Complications/prevention & control, Rabbits, Range of Motion, Articular/physiology, Stress, Mechanical, Tendon Injuries/ drug therapy/physiopathology/ surgery, Tissue Adhesions/ prevention & control
Postens nummer:
158500
Posten skapad:
2012-06-05 09:35
Posten ändrad:
2013-01-31 14:54