transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Interleukin-6 Receptor alpha is Co-localised with Melanin-Concentrating Hormone in Human and Mouse Hypothalamus

Författare och institution:
Erik Schéle (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); C. Fekete (-); P. Egri (-); T. Fuzesi (-); M. Palkovits (-); E. Keller (-); Z. Liposits (-); B. Gereben (-); Linda Karlsson-Lindahl (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Ruijin Shao (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); John-Olov Jansson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
Journal of Neuroendocrinology, 24 ( 6 ) s. 930-943
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Interleukin (IL)-6 deficient mice develop mature-onset obesity. Furthermore, i.c.v. administration of IL-6 increases energy expenditure, suggesting that IL-6 centrally regulates energy homeostasis. To investigate whether it would be possible for IL-6 to directly influence the energy homeostasis via hypothalamic regulation in humans and rodents, we mapped the distribution of the ligand binding IL-6 receptor a (IL-6Ra) in this brain region. In the human hypothalamus, IL-6Ra-immunoreactivity was detected in perikarya and first-order dendrites of neurones. The IL-6Ra-immunoreactive (-IR) neurones were observed posterior to the level of the interventricular foramen. There, IL-6Ra-IR neurones were located in the lateral hypothalamic, perifornical, dorsal and posterior hypothalamic areas, the hypothalamic dorsomedial nucleus and in the zona incerta. In the caudal part of the hypothalamus, the density of the IL-6Ra-IR neurones gradually increased. Double-labelling immunofluorescent studies demonstrated that IL-6Ra immunoreactivity was localised in the same neurones as the orexigenic neuropeptide, melanin-concentrating hormone (MCH). By contrast, IL-6Ra-immunoreactivity was not observed in the orexin B-IR neurones. To determine whether the observed expression of IL-6Ra is evolutionary conserved, we studied the co-localisation of IL-6Ra with MCH and orexin in the mouse hypothalamus, where IL-6Ra-immunoreactivity was present in numerous MCH-IR and orexin-IR neurones. Our data demonstrate that the MCH neurones of the human hypothalamus, as well as the MCH and orexin neurones of the mouse hypothalamus, contain IL-6Ra. This opens up the possibility that IL-6 influences the energy balance through the MCH neurones in humans, and both MCH and orexin neurones in mice.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
IL-6; obesity; orexin; hypocretin
Postens nummer:
Posten skapad:
2012-06-01 15:06
Posten ändrad:
2016-04-08 10:57

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007