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Göteborgs universitets publikationer

Antihypertensive effect of low-frequency transcutaneous electrical nerve stimulation (TENS) in comparison with drug treatment

Författare och institution:
Jonas Silverdal (-); Georgios Mourtzinis (-); Elisabet Stener-Victorin (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Clas Mannheimer (-); Karin Manhem (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Blood pressure, 21 ( 5 ) s. 306-310
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Hypertension is a major risk factor for vascular disease, yet blood pressure (BP) control is unsatisfactory low, partly due to side-effects. Transcutaneous electrical nerve stimulation (TENS) is well tolerated and studies have demonstrated BP reduction. In this study, we compared the BP lowering effect of 2.5 mg felodipin once daily with 30 min of bidaily low-frequency TENS in 32 adult hypertensive subjects (mean office BP 152.7/90.0 mmHg) in a randomized, crossover design. Office BP and 24-h ambulatory BP monitoring (ABPM) were performed at baseline and at the end of each 4-week treatment and washout period. Felodipin reduced office BP by 10/6 mmHg (p <0.001 respectively) and after washout BP rose to a level still significantly lower than at baseline. TENS reduced office BP by 5/1.5 mmHg (p <0.01, ns). After TENS washout, BP was further reduced and significantly lower than at baseline, but at levels similar to BP after felodipin washout and therefore reasonably caused by factors other than the treatment per se. ABPM revealed a significant systolic reduction of 3 mmHg by felodipin, but no significant changes were noted after TENS. We conclude that our study does not present any solid evidence of BP reduction of TENS.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
blood pressure, felodipin, hypertension, transcutaneous electrical nerve stimulation, TENS, treatment
Postens nummer:
Posten skapad:
2012-05-22 15:27
Posten ändrad:
2016-06-10 11:30

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