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Göteborgs universitets publikationer

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Författare och institution:
Georg B. Ehret (-); Patricia B. Munroe (-); Kenneth M. Rice (-); Murielle Bochud (-); Andrew D. Johnson (-); Daniel I. Chasman (-); Albert V. Smith (-); Bruce M. Psaty (-); Gonçalo R. Abecasis (-); Aravinda Chakravarti (-); Paul Elliott (-); Cornelia M. van Duijn (-); Christopher Newton-Cheh (-); Daniel Levy (-); Mark J. Caulfield (-); Toby Johnson (-); ICBP-GWAS (-); Annika Rosengren (Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin)
Publicerad i:
Nature, 47 ( 478 ) s. 103–109
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Genetics and genomics, Disease, Genetics and genomics, Health and medicine
Ytterligare information:
The International Consortium for Blood Pressure Genome-Wide Association Studies These authors contributed equally to this work. Georg B. Ehret, Patricia B. Munroe, Kenneth M. Rice, Murielle Bochud, Andrew D. Johnson, Daniel I. Chasman, Albert V. Smith, Bruce M. Psaty, Gonçalo R. Abecasis, Aravinda Chakravarti, Paul Elliott, Cornelia M. van Duijn, Christopher Newton-Cheh, Daniel Levy, Mark J. Caulfield & Toby Johnson
Postens nummer:
Posten skapad:
2012-01-11 14:49
Posten ändrad:
2012-01-11 16:11

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